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Adjuvant treatments Whether the use of adjuvant chemotherapy after resection of liver CRC metastases can decrease the rate of disease recurrence is still a matter of debate. Results from RCT are controversial. A first study failed to show any survival benefit following adjuvant 5-fluorouracil (5-FU)based HAI chemotherapy (22), which is supported by subsequent non-randomized studies (23). Another RCT comparing adjuvant HAI/systemic chemotherapy to systemic chemotherapy alone showed a trenddoi:10.2741/1761 pmid:15970559 fatcat:rlkxunucfna33litvbaxyv6a4a