Gradski zavod za hitnu medicinsku pomoe, Beograd U radu je prikazan slucaj zadesnog predoziranja digoksinom pod neobicnim okolnostima. Bolesnik starosti od 80 god., Ila redovnoj terapiji digoksinom, zbog cestih' epizoda depresije pocinje da koristi ca] od kantariona (do 2 1dnevno). Nakon njegove obustave razvija se tipicna klinicka slika trovanja digitalisom, potvrdena EKG nalazom nodalne bradikardije oko 361mill i bigeminijom. Ispoljeni simptomi su posledica interakcije istovremeno primenjenog

more »

... preparata od kantariona i digoksina i prestanka uzimanaja kantariona nakon toga. Terapija je ista kao kod klasicnog trovanja digitalisom. Korisnicima ovih preparata se preporucuje postepeni prekid uzimanja preparata kantariona, i to posle konsultovanja sa lekarom. K Ij u C n ere c i : trovanje; digoksin; bforaspolozivost; kantarion; aritmija; bradikardija. Dvod Kantarion ili blago svetog Jovana (Hypericum perforatums je biljka ciji se cajevi i ulja koriste kao antiseptici iii 21. Landauer JA. Magnesium deficiency and digitalis toxicity. JAMA 1984; 251(6): 730. Rad je primljen 24. X 2002. god. Abstract Andelit S. Vojnosanit Preg12003; 60(3): 361-364. BIGEMINY -A RESULT OF DIGOXIN AND ST JOHN'S WORT INTERACTION A case of an by digoxin under unusual circumstances is reported. An so-yearold man, previously on long-term digoxin treatment, started consuming St John's wort herbal tea (2 000 ml/daily) because of frequent episodes of depression. After the cessation of consuming herbal tea containing Hypericum perforatum, digoxin poisoning developed in our patient. Electrocardiography revealed nodal bradicardia 36/min and bigeminy. Manifested symptoms were the consequence of interaction between digoxin and Hypericum perforatum which were consumed simultaneously, and the cessation of consuming St John's wort herbal tea afterwards. Therapy was the same as in the standard digitalis poisoning. Consumers of St John's wort combined with medical products are advised not to discontinue tea consumption on their own, without consulting their physician. Key w 0 r d s : polsoninq; digOXin; biological availability; hyperlcum: arrhythmia; bradycardia. Correspondence to: Sladana Andelic, Gradski zavod za hitnu medicinsku pomoc, Pariske komune 61/132, 11070 Novi Beograd, Srbija i Crna Gora. Tel. +381 II 609645.