We present the principle of the dnaSET, a novel device for single-molecule sequence analysis of DNA strands. The central idea is to measure the variations in current through a single electron transistor (SET) as a target DNA molecule slithers through a nanoeye integrated between the SET's floating island and gate. We present a basic but illustrative simulation of the operation, and the results therefrom lead us to conclude that the dnaSET has a singlenucleotide resolution that enables it to

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... off the individual bases in a DNA strand. The versatility of this idea makes it suitable for incorporation in other bio-assay tools, and thus the dna/proteinSET promises to be a powerful direct sensing device for a wide range of applications. Index Terms-Affinity sensors, deoxyribonucleic acid (DNA), DNA chip/sensors, dnaSET, nanoeye, sequence analysis, single electron transistor (SET), single-molecule sensing, single-stranded DNA (ssDNA).