ANTHELMINTIC ACTIVITY OF SESAMUM INDICUM (L.) SEEDS EXTRACT ON INDIAN EARTHWORM

Supriya Bhandare
INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY   unpublished
Sesamum indicum L., popularly known as black sesame in India, belongs to family pedaliaceae. The objective of the present work was to evaluate the In-vitro anthelmintic potency of the ethanolic extract of Sesamum indicum L. seeds using Indian earthworms (Pheretima posthumad). The various concentrations (25,50,75, 100, 150 and 200mg/ml) of the petroleum ether and ethanolic extracts extract were tested In-vitro for anthelmintic potency by determination of time of paralysis and time of death of
more » ... m. Piperazine citrate (15mg/ml) used as standard. The result of present study indicates that Sesamum indicum potentiate to paralyze earthworm and also caused its death after some time. The shortest time of paralysis was observed at higher dose (200 mg/ml) of both ethanolic and petroleum ether extract were found to 18.01 min and 95.67 min respectively. The results of the study are comparable to standard piperazine citrate. The result showed alcoholic extracts of Sesamum indicum L. seeds took less time to cause paralysis of the earthworm than that of petroleum extract Sesamum indicum L. seeds. Thus the present study demonstrate that the traditional claim of Sesamum indicum L. as an anthelmintic has been confirm as the ethanolic and petroleum ether extracts of seeds displayed activity against the earthworm used in study.
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