To observe changes of tissue factor pathway (TFP) parameters and their ratios in Uyghur and Han ethnic patients with acute myocardial infarction (AMI) in Urumqi, Xinjiang of China. Plasma tissue factor (TF), tissue factor pathway inhibitor (TFPI), activated Factor VII (FVIIa), FVII antigen (FVIIAg) levels were detected by ELISA. FVII coagulant activity (FVII:C) was checked using first-stage coagulation method. TFP parameters were measured in 207 healthy middle-and old-aged people (101 Uygur,

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... Han); TFP parameters of another 90 patients with AMI (31 Uygur, 59 Han) were measured during the same time period and compared with those of the health control group. The results showed that there were significant differences in TF, total-TFPI (t-TFPI), free-TFPI (fl-TFPI), treat-TFPI (tr-TFPI), and the ratios of three TFPI parameters between AMI group and healthy control group were also statistically significant (P<0.05, P<0.01). FVII:C, FVIIa and the ratio of FVIIa/FVIIAg were significantly higher in AMI group than those in healthy controls (P<0.05). In AMI group, tr-TFPI/fl-TFPI and tr-TFPI/t-TFPI ratio in Uyghur patients were significantly lower than those in Han patients (P<0.05). In healthy control, tr-TFPI, TF/fl-TFPI and tr-TFPI/t-TFPI ratio of Uyghur group were significantly lower than those in Han healthy (P<0.05). In conclusion, except that tr-TFPI in healthy Uyghur was lower than that in healthy Han people, there was no significant difference in the other TFP parameters between the two ethnic healthy groups. Higher levels of TF/tr-TFPI, lower levels of tr-TFPI/fl-TFPI and tr-TFPI/t-TFPI ratio in AMI groups demonstrated the high-coagulation state during the acute stage of AMI. The ratios between the various TFP parameters are more reliable than single parameter in assessing the high-coagulation state and risk factors in cardiovascular thrombotic disease.