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Elevated Plasma Glucose-Dependent Insulinotropic Polypeptide Associates With Hyperinsulinemia in Impaired Glucose Tolerance
OBJECTIVE -The role of gut-derived incretin, glucose-dependent insulinotropic polypeptide (also known as gastric inhibitory peptide [GIP]), in compensatory ␤-cell hypersecretion during insulin-resistant states and in transition to ␤-cell failure in type 2 diabetes is unknown. RESEARCH DESIGN AND METHODS -We carried out oral glucose tolerance testing followed by blood sampling 10 times for 2 h on 68 age-and BMI-matched participants of the Baltimore Longitudinal Study on Aging (BLSA) with normaldoi:10.2337/diacare.27.7.1692 pmid:15220248 fatcat:6vmxasbfgbhjlk3adzd7wcq4ji