Local Delivery of Stromal Cell-Derived Factor-1α Improves the Pregnancy Rate of Injured Uterus through the Promotion of Endometrial and Vascular Regeneration [article]

Hongxai Cai, Bingbing Wu, Yixiao Liu, Yu Li, Libing Shi, Lin Gong, Yaxian Xia, BoonChin Heng, Huiling Wu, Hongwei Ouyang, Zhenghua Zhu, Xiaohui Zou
2018 bioRxiv   pre-print
Severe infection and mechanical injury of the uterus may lead to infertility and miscarriage. Currently, there is a lack of effective treatment modality for functional repair of uterine injury. To address this clinical challenge, this study aimed to develop a chemotactic composite scaffold by incorporating recombinant human stromal cell-derived factor-1α (rhSDF-1α) into a silk fibroin-bacterial cellulose (SF-BC) membrane carrier. A rat model of uterine injury was utilized for this study, which
more » ... this study, which was composed of three groups: blank control, implantation with SF-BC only or SF-BC loaded with rhSDF-1α. The tissue regeneration efficacy of the three groups were analyzed and compared. The results showed that SF-BC loaded with rhSDF-1α significantly enhanced endometrial regeneration and arteriogenesis of the injured rat uterus, which led to improved pregnancy outcomes, thus indicating much promise for functional uterine repair and regeneration.
doi:10.1101/251579 fatcat:m4e2sytypzbahihijsqd6ykyde