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4. After demonstrating the organism in a primary lesion it is not only unnecessary but harmful to wait for secondary manifestations. The most logical therapy is excision of the chancre when possible, and in a/I cases the immediate institution of the vigorous antisyphilitic treatment. In conclusion we wish to call attention to the great value of the dark ground illuminator for the demonstration of the Spirochwta pallida and to emphasize the necessity and value of the demonstration of thedoi:10.1001/jama.1908.25410230019001e fatcat:sipgbiwa3jgopaspxylzbxheui