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Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense
2016
Cellular and Molecular Life Sciences (CMLS)
Trypanosoma brucei rhodesiense is one of the causative agents of human sleeping sickness, a fatal disease that is transmitted by tsetse flies and restricted to Sub-Saharan Africa. Here we investigate two independent lines of T. b. rhodesiense that have been selected with the drugs melarsoprol and pentamidine over the course of 2 years, until they exhibited stable cross-resistance to an unprecedented degree. We apply comparative genomics and transcriptomics to identify the underlying mutations.
doi:10.1007/s00018-016-2173-6
pmid:26973180
pmcid:PMC4967103
fatcat:pcl62svulvbv3jvkfquv5ne2c4