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Positron emission tomography (PET) imaging is based on detecting two time-coincident highenergy photons from the emission of a positron-emitting radioisotope. The physics of the emission, and the detection of the coincident photons, give PET imaging unique capabilities for both very high sensitivity and accurate estimation of the in vivo concentration of the radiotracer. PET imaging has been widely adopted as an important clinical modality for oncological, cardiovascular, and neurologicaldoi:10.1146/annurev-bioeng-071114-040723 pmid:26643024 pmcid:PMC5299095 fatcat:5mwg2in42bcr7eic3qiii7utci