Positron Emission Tomography: Current Challenges and Opportunities for Technological Advances in Clinical and Preclinical Imaging Systems

Juan José Vaquero, Paul Kinahan
2015 Annual Review of Biomedical Engineering  
Positron emission tomography (PET) imaging is based on detecting two time-coincident highenergy photons from the emission of a positron-emitting radioisotope. The physics of the emission, and the detection of the coincident photons, give PET imaging unique capabilities for both very high sensitivity and accurate estimation of the in vivo concentration of the radiotracer. PET imaging has been widely adopted as an important clinical modality for oncological, cardiovascular, and neurological
more » ... ations. PET imaging has also become an important tool in preclinical studies, particularly for investigating murine models of disease and other small-animal models. However, there are several challenges to using PET imaging systems. These include the fundamental trade-offs between resolution and noise, the quan-titative accuracy of the measurements, and integration with X-ray computed tomography and magnetic resonance imaging. In this article, we review how researchers and industry are addressing these challenges.
doi:10.1146/annurev-bioeng-071114-040723 pmid:26643024 pmcid:PMC5299095 fatcat:5mwg2in42bcr7eic3qiii7utci