Elevated Serum TNF – α and Decreased IL-6 levels in Iraqi Women with First Trimester Missed and Threatened Miscarriage Compared to Healthy Pregnancy

Khitam Ali, Amany Sahib
2011 Bulletin of Egyptian Society for Physiological Sciences  
Objective: To measure serum tumor necrosis factor-alpha (TNF-α) and in Iraqi women with first trimester missed and threatened miscarriage and compare their levels with those of normal pregnancy. Methods: A case control study was conducted from , Iraq. Samples were obtained from 62 pregnant women in the first trimester: eighteen women with threatened miscarriage ( A and D (17.68±2.90 pg/ml., 9.75±1.66 pg/ml. and. 4.41±1.23 pg/ml., p=0.039 and p=0.0001 respectively). A significant decrease in
more » ... ant decrease in mean serum p=0.014). No significant correlation was found between serum levels of TNF-α and IL-6 in all subjects. Conclusion: TNF-α might play an important role in the process of missed and threatened miscarriage and IL-6 may be an important factor for healthy pregnancy. group A), 22 with missed miscarriage (group B), 22 apparently healthy pregnant (group C) (positive controls) matched in age and body mass index (BMI) and 23 non-pregnant women (group D) (negative controls). The concentrations of serum TNF-α and IL-6 were determined by an enzyme immunometric assay (EIA). Results: Serum TNF-α levels in group B showed a highly significant increase compared to group
doi:10.21608/besps.2011.35956 fatcat:kivpen46pve7toyff5j5nbrs44