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IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes
2019
Journal of Clinical Investigation
Type 1 IFNs (IFN-I) generally protect mammalian hosts from virus infections, but in some cases, IFN-I is pathogenic. Because IFN-I is protective, it is commonly used to treat virus infections for which no specific approved drug or vaccine is available. The Middle East respiratory syndrome-coronavirus (MERS-CoV) is such an infection, yet little is known about the role of IFN-I in this setting. Here, we show that IFN-I signaling is protective during MERS-CoV infection. Blocking IFN-I signaling
doi:10.1172/jci126363
pmid:31355779
pmcid:PMC6715373
fatcat:r3prw5smizdlpherbio3kw2nca