PP-119 Long term protection of HBV vaccination

D. Tungalag, B. Baigal, O. Baatarkhuu, N. Chorolsuren, R. Oyungerel, G. Zulkhuu, Y. Dahgwahdorj
2011 International Journal of Infectious Diseases  
Abstracts, 5th DICID Conclusions: There were skewed Treg/Th17 ratios during HBV infection. The imbalance of Treg/Th17 ratios existed in CHB and ACHBLF patients and the imbalanced expression of Treg/Th17 cells might contribute to HBV persistence. PP-116 The prevalence of hepatitis delta virus (HDV) and different ethnical groups in Sind, Pakistan Background and Aim: In Asia-Pacific region HBeAg infection along with HDV is a major health concern. Approximately 18 million people are estimated to be
more » ... are estimated to be involved in HDV infection. The trend of HDV disease is almost decreasing from the European region, but increasing in South Asia countries due to favorable spreading conditions for Hepatitis B and other related diseases. The true existing data are not available from most of the countries including the Pakistan. We studied the prevalence of HDV infection among different ethnical groups in Sind, Pakistan. Method: The data collected from 533 total patients of the two major hospitals of two different cities of province Sind, Pakistan which were presenting the ISRA University, Hyderabad and Aga Khan University Karachi in last three years. Among them we found 480 patients of HBeAg with HDV positive DNA PCR detectable. Results: We found in our study that the prevalence of HDV was 40% based on antibody results among the patients serum who were attending the tertiary care hospitals for detection of HBsAg. The mean age was 32.67 years (median 31.00 years, range 3 80). Males were more affected 424 (79.5%) as compared to the female 109 (20.4%). The ethnically the Sindhi speaking were 67%, Urdu 14%, pathan 6.6%, Balochi 8.1% and rest were in the others. Moreover, the study showed that 415 (77.8%) were literate people, we further divide the ethnic groups into two Sindhi and Non-Sindhi categories, among them 51 positive and 12 positive cases were found respectively on the bases of HDV RNA Qualitative test. Conclusion: The Prevalence of HDV infection among our region of Pakistan seems to be very high and increasing in Sindhi rural areas, which is alarming situation. This infection occurred in all age groups particularly in the males because they are frequently exposed to the spreading risk factors. Introduction: Viral hepatitis (VH) infections are hyper endemic in Mongolia. So, problem of VH is always in center of Government attention. Therefore, HBV vaccination introduced as mandatory immunization since 1991. Objective: To study the rate of exposure of HBV infection in vaccinated and nonvaccinated population during 20 years.
doi:10.1016/s1201-9712(11)60271-3 fatcat:jyfwfdb735hk5nw2i4q2usdkly