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To enhance the practical applicability of the calibrated automated thrombogram (CAT) we investigated whether frozen-thawed platelet-rich plasma (ft-PRP) can be used to assess the function of the protein C inhibitory pathway, while preserving the natural phospholipid composition. Recalcified ft-PRP triggered with 0.5 pM recombinant human tissue factor shows a median thrombin potential of 1,719 nM.min, against 1,576 nM. min for fresh PRP. To obtain -70% inhibition. 6.7 nM activated protein Cdoi:10.1159/000071638 pmid:12853709 fatcat:t75zo2agxrcntee47psgbpdjpe