Time to Bring Single Neuron Modeling into 3D

Weiliang Chen, Erik De Schutter
2017 Neuroinformatics  
Almost all single neuron models currently being used and developed combine discretized cable models with Hodgkin-Huxley type equations. 1 This approach, employed by the popular software package NEURON 2 and its competitors such as GENESIS, 3 MOOSE, 4 etc., is based on mathematical methods developed in the 50s and 60s, before supercomputers were available for scientific research. Wilfrid Rall introduced linear cable theory to analyze the electrical behavior of dendrites 5 and was the first to
more » ... onstrate their importance for synaptic integration. 6 Later he proposed a computational approach, called compartmental modeling, based on a spatial discretization of the linear cable equation. 7 Although compartmental modeling allows simulation of the complex 3D morphology of dendrites and axons in reasonable detail, the underlying equations ignore many 3D aspects by computing the changes in membrane potential in a branched 1D cable.
doi:10.1007/s12021-016-9321-x pmid:28058618 fatcat:puxlalg6jjdzjo4u5neldkum7u