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BAP1 deubiquitinase is a potent repressor of fetal hemoglobin biosynthesis
[article]
2018
bioRxiv
pre-print
Human globin gene production transcriptionally switches from fetal to adult synthesis shortly after birth, and is controlled by macromolecular complexes that enhance or suppress transcription by cis-elements scattered throughout the locus. The DRED repressor is recruited to the epsilon- and gamma-globin promoters by the orphan nuclear receptors TR2 (NR2C1) and TR4 (NR2C2) to engender their silencing in adult erythroid cells. Here we found that nuclear receptor corepressor-1 (NCoR1) is a
doi:10.1101/346619
fatcat:25zxe3oabzdchm7zl2pi4zzzeq