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Investigating the clavam gene cluster in Streptomyces antibioticus Tü1718
2011
Production of clavams (including clavulanic acid, a potent β-lactamase inhibitor) has been studied in Streptomyces clavuligerus. All clavams share the early biosynthetic steps. However, many of the late steps of the pathway remain unclear. Streptomyces antibioticus Tü1718 was chosen for this study because it produces two 5S clavams (different from clavulanic acid in their stereochemistry) and no clavulanic acid. After screening a cosmid library of the gDNA of this bacterium for a cas gene
doi:10.7939/r3d93t
fatcat:yl2kxegstzbnvolsteyc4xlzoe