Formulation and Evaluation of Floating Tablets of Ranitidine Hydrochloride with Liquorice as Natural Ulcer Protective Agent

Poonam Sansarwal, Sunaina Sharma, Richa Ohri
2019 International journal of pharmacy and pharmaceutical research  
The concurrent trend in pharmaceutical evolution accentuates the effectiveness of floating tablets over conventional dosage form. Furthermore, it facilitates site-specificity, controlled release and is irrespective of gastric emptying. The present study was carried out to enhance the bioavailability of Ranitidine HCl, a floating dosage form with controlled release. Ranitidine HCl has a narrow absorption window in the gastrointestinal tract; therefore its absorption was improved by modifying the
more » ... ed by modifying the dosage form. The action potential of a drug is synergized by combining it with a natural ulcer protective agent that is liquorice. The tablets were prepared by wet granulation method. The batches were formulated using a different ratio of HPMC K15 and Carbopol. It ensures the effectiveness of the formulation variable on drug release and buoyancy property of the delivery system. The prepared formulations show significant results obtained by pharmacopoeial quality control tests. In-vitro dissolution study was also performed to check whether the ratio of polymers was optimum for controlled release or not. The present study suggests that the Ranitidine HCl and liquorice together are well compatible with each other. However, the effectiveness of the drug combination partially depends upon the ratio of polymers. glycyrrhetinic acid[7, 8]. Liquorice elevates prostaglandin concentration in the digestive system that assists mucous secretion. Also, the antipepsin effect of liquorice perpetuates the life span of surface cells in the stomach[9]. www.ijppr.humanjournals.com Liquorice(extracted received as a gift sample from Konark herbal and health care, Kala Amb, H.P), Citric acid, Sodium bicarbonate, Carbopol, HPMC K15, Talc, Magnesium stearate, Ethanol, Hydrochloric acid, Sodium hydroxide, Potassium hydrogen diphosphate (SD fine chemicals). METHODS Construction of Calibration Curve: Preparation of simulated gastric fluid (SGF)[10] 2 g of sodium chloride was dissolved in 500 ml deionized water, followed by adding 7 ml of concentrated HCl and final volume made up to 1000 ml with water. The pH of the solution was adjusted to 1.2 with 0.1N HCl. Preparation of sample solutions of Ranitidine HCl The primary stock solution was prepared by dissolving 112 mg of pure Ranitidine HCl equivalent to 100 mg in 100ml SGF pH 1.2 to get a concentration of 1mg/ml. Secondary stock solution 5ml was pipetted out from the primary stock solution and transferred into 50 ml volumetric flask, the final volume was made up to 50 ml using SGF pH 1.2 Further sample solution of concentration 20 µg/ml, 40 µg/ml, 60 µg/ml, 80 µg/ml, 100 µg/ml were prepared from secondary stock solution. The absorbance was measured at 314 nm by UV spectrophotometer (Labindia Analytical) using SGF pH 1.2 as a blank solution. The calibration curve was plotted against concentration (x-axis) and absorbance (y-axis). Compatibility studies: Were performed by FT-IR of drug liquorice and polymers, and then interpretation was done to check compatibility. www.ijppr.humanjournals.com
doi:10.25166/ijppr.2020.v17i01.04 fatcat:bj2ukajaavhu7pxsg2kvbwtupi