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The aim of this paper was to validate an analytical method for the simultaneous determination of PTX and its active metabolite (-)-(R)-M1 in rat serum and some tissues using a high-performance liquid chromatography method with ultraviolet detection (HPLC-UV). The specificity, linearity, precision, accuracy, recovery, lower limit of detection, lower limit of quantification and stability study were successively conducted according to GLP procedures. HPLC separation of all compounds was carriedpmid:19645320 fatcat:k43iufh5cfdr3nxum66tc6agvm