Bidirectional Modulation of Hippocampal Long-Term Potentiation under Stress and No-Stress Conditions in Basolateral Amygdala-Lesioned and Intact Rats

V. Korz
2005 Journal of Neuroscience  
Hippocampal long-term potentiation (LTP) is widely considered as a cellular model for learning and memory formation. We have shown previously that protein synthesis-independent, early dentate gyrus (DG) LTP, lasting ϳ4 -5 h, can be transformed into a late-LTP with a duration of Ն24 h by a brief acute swim stress experience (high-stress condition). This reinforcement requires the activation of mineralocorticoid receptors and protein synthesis. The basolateral amygdala (BLA) is known to modulate
more » ... lucocorticoid effects on the consolidation of spatial/contextual memory via a ␤-adrenergic mechanism. Interestingly, hippocampal DG-LTP can also be indirectly modulated by ␤-adrenergic and cholinergic/muscarinergic processes. Here, we show that the reinforcement of early-DG-LTP under high-stress conditions depends on the processing of novel spatial/contextual information. Furthermore, this reinforcement was blocked in BLA-lesioned animals compared with sham-operated and intact controls; however, it was not dependent on ␤-adrenergic or cholinergic/muscarinergic receptor activation. In contrast, under low-stress conditions, the induction of late-LTP in BLA-lesioned animals is facilitated, and this facilitation, again, was dependent on ␤-adrenergic activation. The data suggest that DG-LTP maintenance can be influenced by the BLA through different mechanisms: a short-lasting corticosterone-dependent and ␤-adrenergic-independent mechanism and a long-lasting mechanism that facilitated hippocampal ␤-adrenergic mechanisms.
doi:10.1523/jneurosci.0910-05.2005 pmid:16093390 fatcat:52qbfquij5edrlh3zq5mffz74u