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Reductive metabolism of the sanguinarine iminium bond by rat liver preparations
2013
Pharmacological Reports
Sanguinarine (SA) is a quaternary benzo [c]phenanthridine alkaloid that is mainly present in the Papaveraceae family. SA has been extensively studied because of its antimicrobial, anti-inflammatory, antitumor, antihypertensive, antiproliferative and antiplatelet activities. Metabolic studies demonstrated that SA bioavailability is apparently low, and the main pathway of SA metabolism is iminium bond reduction resulting in dihydrosanguinarine (DHSA) formation. Nevertheless, the metabolic enzymes
doi:10.1016/s1734-1140(13)71498-1
pmid:24399736
fatcat:ccystxunbvdhpn3iujmsaxmhvm