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Bioimaging assessment and effect of skin wound healing using bone-marrow-derived mesenchymal stromal cells with the artificial dermis in diabetic rats
Journal of Biomedical Optics
We investigate the relationship between the fate and healing effect of transplanted mesenchymal stromal cells ͑MSCs͒ in a rat diabetic skin wound model. Rats are treated with streptozotocin to induce diabetic conditions. A full-thickness skin defect is surgically made on the head of diabetic rats, and covered with an artificial dermis impregnated with either bone marrow cells ͑BMCs͒ or bonemarrow-derived MSCs from firefly luciferase ͑luc͒ transgenic ͑Tg͒ rats. Wound healing is evaluated usingdoi:10.1117/1.3042266 pmid:19123682 fatcat:y76f7obl25fo5ps5czs2jzprve