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Motivation: Authors of several recent papers have independently introduced a family of transformations (the generalizedlog family), which stabilizes the variance of microarray data up to the first order. However, for data from two-color arrays, tests for differential expression may require that the variance of the difference of transformed observations be constant, rather than that of the transformed observations themselves. Results: We introduce a transformation within the generalizedlogdoi:10.1093/bioinformatics/btg464 pmid:15033873 fatcat:rbbz3meu2zci5nm2gf57mkapgq