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2 Degradation of clofarabine (3) in 0.9% saline solution at 100 • C afforded three degradation products which were determined to be formamidopyrimidines 4-6.Compounds 4 and 5 were assigned as C 1 anomers on the basis of one-dimensional and two-dimensional NMR experiments, whereas 6 was found to be the formamidopyrimidine lacking the sugar moiety. An improved procedure for the synthesis of formamidopyrimidines was developed, wherein benzoylated clofarabine (11) was treated with allyldoi:10.1080/15257770802257770 pmid:18696361 fatcat:tqyuhwys7jgn5o5f5ifqxpnmoa