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Simultaneous inhibition of cholesterol absorption and synthesis in combined therapy with ezetimibe and simvastatin
CARDIOVASCULAR THERAPY AND PREVENTION
This review is devoted to pharmacological characteristics, action mechanisms, hypolipidemic activity, and pleiotropic effects of a new hypolipidemic medication – ezetimibe, inhibiting intestinal cholesterol absorption. The combination of ezetimibe with other hypolipidemic drugs (statins, fibrates, bile acid sequestrants) is described in detail. Initial doses of various statins, together with one tablet (10 mg) of ezetimibe, reduce low-density cholesterol level as effectively as maximal statin doses.doaj:169ba388308d4762bc0734e86fe19a8a fatcat:5yrjhmy32vasdfm7oj7j7olk4e