A FACILE SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF CARBAMAZEPINE IN TABLETS

Jayanna, T Devaraj, Ninge Gowda, Jayanna
2014 Indian Journal of Drugs   unpublished
A simple spectrophotometric method was developed and validated for the quantification determination of carbamazepine in tablet formulation. The method is based on formation of nitrosamine by a specific reaction of carbamazepine with nitrite under acid condition. Carbamazepine undergoes nitrosation forming greenish yellow product and the absorbance measured at 417 nm. All the optimum conditions are established. The calibration graphs are rectilinear in the concentration ranges 0.2-10 μg / ml in
more » ... 0.2-10 μg / ml in the final measured solution. The Sandell sensitivity (S), molar absorptivity, correlation coefficient, regression equations are calculated. The proposed method is applied for the assay of drug in pharmaceutical dosage forms. The results are in good agreement with the label claim.
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