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Indian Journal of Drugs
A simple spectrophotometric method was developed and validated for the quantification determination of carbamazepine in tablet formulation. The method is based on formation of nitrosamine by a specific reaction of carbamazepine with nitrite under acid condition. Carbamazepine undergoes nitrosation forming greenish yellow product and the absorbance measured at 417 nm. All the optimum conditions are established. The calibration graphs are rectilinear in the concentration ranges 0.2-10 μg / ml infatcat:4ctvosyaffcxli4el5nvm2ftkm