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Metronidazole is an antiprotozoal drug, which has broad spectrum cidal activity against anaerobic protozoa and microaerophillic bacteria. Aphthous ulcer is a very rare side effect with metronidazole. Here we report a case of 55 year old male suffered from metronidazole induced aphthous ulcer with angular cheilitis.fatcat:ni4q7ecwrbestobzwgwqopbi2q