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Objective The Circle of Willis (CoW) is often underdeveloped or incomplete, leading to suboptimal blood supply to the brain. As hypoperfusion is thought to play a role in the aetiology of white matter hyperintensities (WMH), the objective of this study was to assess whether incomplete CoW variants were associated with increased WMH volumes compared to the complete CoW. Methods In a cross-sectional population sample of 1864 people (age 40 - 84 years, 46.4% men), we used an automated method todoi:10.1101/2020.09.25.20183756 fatcat:wpuil2u7pvcynatqss4mnjz224