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Storage of large molecular dynamics (MD) simulation measurements in standard databases is a challenging task. The requirements on disk space, input/output (I/O) and data transfer bandwidth are excessively high due to the large volume, possibly terabytes or petabytes, of data generated. Storage of data in compressed form has been a popular approach to address such issues. In this paper, we present a lossy compression framework that yields significant performance gain by combining the strength ofdoi:10.1016/j.bpj.2010.12.2875 fatcat:p2ok3tuyfjgebbsdjhepjdrpse