The following articles are being highlighted as part of Circulation's Topic Review series. This series will summarize the most important manuscripts, as selected by the editors, published in Circulation and the Circulation subspecialty journals. The studies included in this article represent the most read manuscripts published on the topic of molecular cardiology in . (Circulation. 2011124:e927-e953.) Conclusion: Exposure exaggerates insulin resistance and visceral inflammation/adiposity. These

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... findings provide a new link between air pollution and type 2 diabetes mellitus. 3 Correspondence to The Editors, Circulation Editorial Office, Summary: Epidemiological studies have shown that women are protected from coronary heart diseases before menopause, which suggests a beneficial action of endogenous estrogens. Consistently, the prevention of early atheroma by estrogens has been demonstrated clearly in several animal models, including mice and monkeys.