Dynamic brain network reconfiguration as a potential schizophrenia genetic risk mechanism modulated by NMDA receptor function

Urs Braun, Axel Schäfer, Danielle S. Bassett, Franziska Rausch, Janina I. Schweiger, Edda Bilek, Susanne Erk, Nina Romanczuk-Seiferth, Oliver Grimm, Lena S. Geiger, Leila Haddad, Kristina Otto (+7 others)
2016 Proceedings of the National Academy of Sciences of the United States of America  
Significance Converging evidence points to a role for glutamate and altered brain network dynamics in schizophrenia, but the molecular and genetic contributions are poorly understood. Here, we applied dynamic network neuroscience methods to neuroimaging working memory data to identify potential alterations in brain network flexibility related to schizophrenia genetic risk and N-methyl-Daspartate (NMDA) receptor hypofunction. Consistent with altered network dynamics, we detected significant
more » ... ases in brain network flexibility in patients with schizophrenia, healthy firstdegree relatives, and healthy subjects receiving a single dose of an NMDA receptor antagonist. Our data identify a potential dynamic network intermediate phenotype related to the genetic risk for schizophrenia and point to a critical role for glutamate in the temporal coordination of neural networks and the pathophysiology of schizophrenia.
doi:10.1073/pnas.1608819113 pmid:27791105 pmcid:PMC5098640 fatcat:qftg6ln4tvcttotamcmxmyirau