The association between low body mass index and arterial stiffness in Africans: The pure study

H.W. Huisman, J.M. Van Rooyen, H.L. Venter, A.E. Schutte, R. Schutte, C.M.T. Fourie, C.M.C. Mels, W. Smith, N.T. Malan, L. Malan
2013 Artery Research  
Objectives: Increased carotid-femoral Pulse Wave Velocity (PWVc-f) identify hypertensive patients at high CV risk, independently of systematic coronary risk evaluation (SCORE). Testosterone is associated with aortic stiffness, however whether this association is different in hypertensive patients with low or intermediate SCORE compared to high SCORE subjects is unknown. Methods: Total testosterone (TT) and PWVc-f were measured in 311 non-diabetic hypertensive men with no evidence of clinical
more » ... ence of clinical atherosclerosis. Hypogonadism (HypG) was defined when TT levels were below 3.4 ng/ml. Results: The prevalence of HypG in hypertensive patients with low, moderate and high SCORE was 12.5, 15.2 and 28.2%, respectively. PWVc-f was significantly associated with TT in low (rZ-0.289, P<0.001) and moderate SCORE (rZ-0.274, P<0.001) patients but not in patients with high SCORE (rZ-0.092, PZ0.33). Subjects were then categorized by SCORE and further subdivided according to presence/absence of HypG. PWVc-f values of each SCORE/testosterone category are shown in figure. In low and moderate SCORE categories, patients with HypG had higher PWVc-f (by 0.92 m/s, P<0.01 and 0.55 m/s, P<0.05, respectively) compared to subjects with TT above the cut off level for biochemical definition of HypG. On the contrary, in high SCORE category, PWVc-f between patients with HypG and men with normal levels did not differ. It can be noted that low and moderate SCORE hypertensive patients with HypG had already elevated PWVc-f as compared to high SCORE men with normal TT. Conclusions: The effect of low testosterone concentration on aortic stiffness is emphasized in hypertensive patients with low and moderate SCORE. Background: Carotid-femoral pulse wave velocity (cfPWV) is an independent predictor of cardiovascular events and its measurement is recommended by current hypertension guidelines. Few data are available on the progression of PWV over time. The aim of the present study was to assess the progression of aortic stiffness over a 5-year period in a general population in Northern Italy (Vobarno Study). Methods: 227 subjects,42% males(age 50AE4 years, hypertension in 51% at baseline visit, BL), underwent a BL and a follow up (FU) visit, after 5.1AE0.4 years. In all subjects laboratory examinations, measurement of clinic and 24 hours blood pressure(BP) and of cfPWV were performed at BL and at FU. Results: In the overall population cfPWV increased from 8.28AE1.27 at BL to 8.51AE3.2 m/s at FU(p<0.05),change:0.22AE1.25.cfPWV significantly
doi:10.1016/j.artres.2013.10.095 fatcat:ecrzpyiz4rabho5b7gh7jmooyu