A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf
.
Genome-wide mapping and analysis of chromosome architecture
2016
Nature reviews. Molecular cell biology
Chromosomes of eukaryotes adopt highly dynamic and complex hierarchical structures in the nucleus. The three-dimensional (3D) organization of chromosomes profoundly affects DNA replication, transcription and the repair of DNA damage. Thus, a thorough understanding of nuclear architecture is fundamental to the study of nuclear processes in eukaryotic cells. Recent years have seen rapid proliferation of technologies to investigate genome organization and function. Here, we review experimental and
doi:10.1038/nrm.2016.104
pmid:27580841
pmcid:PMC5763923
fatcat:2eyv2yjh2rcc5nbzpmvtv5bv2a