Disposable Microdevices for DNA Analysis and Cell Sorting

H.-P. Chou, C. Spense, A. Fu, A. Scherer, S. Quake
1998 1998 Solid-State, Actuators, and Microsystems Workshop Technical Digest   unpublished
We have developed microfabricated devices to size and sort microscopic objects, based on measurement of fluorescent properties. With these devices, we have demonstrated sizing and sorting on various biological entities, ranging from E. Coli cells to single molecules of DNA. The microfabricated devices have several advantages over macroscopic systems, including size, cost and sensitivity. For example, the detection volume for our devices is 375 femtoliters, more than an order of magnitude
more » ... of magnitude smaller than what has been achieved with flow cytometry. 0-9640024-2-6/hh1998/$20©1998TRF
doi:10.31438/trf.hh1998.3 fatcat:wr2yvslal5erpg46ziwxdzc6bu