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Folding & design
Computer experiments and analytical estimates have shown that protein and RNA chains can reach their most stable folds without an exhaustive search over all their possible conformations. Protein-like chain folding proceeds via a specific nucleus and under conditions optimal for the fastest folding of these chains the dependence of the folding time (t) on the chain length (L) is in accord with the power law t~L b (b is a constant). Results: Using Monte-Carlo folding simulations for a simpledoi:10.1016/s1359-0278(98)00012-1 pmid:9565751 fatcat:ftagisq3rzemloabr7vp3e7pdi