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Lanthanum triflate triggered synthesis of tetrahydroquinazolinone derivatives of N-allyl quinolone and their biological assessment
2012
Journal of the Serbian Chemical Society
Preserved Fulltext
A series of 24 derivatives of tetrahydroquinazolinone has been synthesized by the one-pot cyclocondensation reaction of N-allyl quinolones, cyclic β-diketones and (thio)urea/N-phenylthiourea in the presence of lanthanum triflate catalyst. This methodology allowed the products to be achieved in excellent yield by stirring at room temperature. All the synthesized compounds were investigated against a representative panel of pathogenic strains using the broth microdilution MIC (minimum inhibitory
doi:10.2298/jsc120121039j
fatcat:te4yuifmubdptnwro464hmqunq