Lanthanum triflate triggered synthesis of tetrahydroquinazolinone derivatives of N-allyl quinolone and their biological assessment

Hardik Jardosh, Manish Patel
2012 Journal of the Serbian Chemical Society  
A series of 24 derivatives of tetrahydroquinazolinone has been synthesized by the one-pot cyclocondensation reaction of N-allyl quinolones, cyclic β-diketones and (thio)urea/N-phenylthiourea in the presence of lanthanum triflate catalyst. This methodology allowed the products to be achieved in excellent yield by stirring at room temperature. All the synthesized compounds were investigated against a representative panel of pathogenic strains using the broth microdilution MIC (minimum inhibitory
more » ... oncentration) method for their in vitro antimicrobial activity. Amongst these sets of heterocyclic compounds 5h, 6b, 6h, 5f, 5l, 5n and 6g were found to have admirable activity.
doi:10.2298/jsc120121039j fatcat:te4yuifmubdptnwro464hmqunq