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RBFOX2 deregulation promotes pancreatic cancer metastasis through alternative splicing
RNA splicing is an important biological process associated with cancer initiation and progression, yet in pancreatic cancer the role and regulation of splicing is not well understood. From a forward genetic screen in a mouse model of pancreatic cancer, we identified an enrichment of RNA binding proteins (RBPs) associated with the spliceosome. Here, we link deregulation of RBFOX2, an RBP of the FOX family, to pancreatic cancer progression and liver metastasis. We show that RBFOX2 regulation indoi:10.1101/2022.06.01.494386 fatcat:whcnqvzgrrbwphh7rl3djuvfwm