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Plasmonic substrates for multiplexed protein microarrays with femtomolar sensitivity and broad dynamic range
2011
Nature Communications
Protein chips are widely used for high-throughput proteomic analysis, but to date, the low sensitivity and narrow dynamic range have limited their capabilities in diagnostics and proteomics. Here we present protein microarrays on a novel nanostructured, plasmonic gold film with near-infrared fluorescence enhancement of up to 100-fold, extending the dynamic range of protein detection by three orders of magnitude towards the fm regime. We employ plasmonic protein microarrays for the early
doi:10.1038/ncomms1477
pmid:21915108
pmcid:PMC3402035
fatcat:v55vm4lakne7tmone75vr3e35i