Chromosomes in normal, preneoplastics, and neoplastic tissues of the mammary glands of C3H/Crgl female mice

1963 Cancer Research  
The significance of the chromosomal aberrations often associated with cancer cell populations is a problem of major concern to oncologists. The asso ciation between chromosomal aberrations and neoplasia was suggested by early studies on ascites tumors (7) . Some investigators consider that kary otypic instability is not essential for the neoplastic transformation (1, 9) . Evidence for these points of view has been considered by Hauschka in a recent review (5). A study of the chromosomes of
more » ... chromosomes of hyper plastic alveolar nodules in the mouse mammary glands could provide critical evidence, because mammary tumors arise from these preneoplastic lesions rather than from adjacent normal tissues.
pmid:13966319 fatcat:rqy2uclr65dxtibrfnsvux3l7m