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The significance of the chromosomal aberrations often associated with cancer cell populations is a problem of major concern to oncologists. The asso ciation between chromosomal aberrations and neoplasia was suggested by early studies on ascites tumors (7) . Some investigators consider that kary otypic instability is not essential for the neoplastic transformation (1, 9) . Evidence for these points of view has been considered by Hauschka in a recent review (5). A study of the chromosomes ofpmid:13966319 fatcat:rqy2uclr65dxtibrfnsvux3l7m