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Sequencing of E2 and NS5A regions of HCV genotype 3a in Brazilian patients with chronic hepatitis
2010
Memórias do Instituto Oswaldo Cruz
Hepatitis C virus (HCV) is a major cause of liver disease throughout the world. The NS5A and E2 proteins of HCV genotype 1 were reported to inhibit the double-stranded (ds) RNA-dependent protein kinase (PKR), which is involved in the cellular antiviral response induced by interferon (IFN). The response to IFN therapy is quite different between genotypes, with response rates among patients infected with types 2 and 3 that are two-three-fold higher than in patients infected with type 1.
doi:10.1590/s0074-02762010000100014
pmid:20209336
fatcat:lfqb47yrz5fvpdhovmbnn62p3a