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Faculty of 1000 evaluation for A novel Drosophila model of nerve injury reveals an essential role of nmnat in maintaining axonal integrity
[dataset]
2012
F1000 - Post-publication peer review of the biomedical literature
unpublished
Axons damaged by acute injury, toxic insults or during neurodegenerative diseases undergo Wallerian or Wallerian-like degeneration, which is an active and orderly cellular process but the underlying mechanisms are poorly understood [1-3]. Drosophila has been proven a successful system for modeling human neurodegenerative diseases [4, 5] . In this study, we established a novel in vivo model of axon injury using the adult fly wing. The wing nerve highlighted by fluorescent
doi:10.3410/f.14245970.15758083
fatcat:phto2ouqlvapffotuwhyrxhewy