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and Purpose-An increase in serum glucose at the time of acute ischemia has been shown to adversely affect prognosis. The mechanisms for the hyperglycemia-exacerbated damage are not fully understood. The objective of this study was to determine whether hyperglycemia leads to enhanced accumulation of extracellular concentrations of excitatory amino acids and whether such increases correlate with the histopathological outcome. Methods-Rats fasted overnight were infused with either glucose ordoi:10.1161/01.str.31.1.183 pmid:10625736 fatcat:sai75wfrovfw3jm7f6x3ggpzdq