Neutrophil-related cytokines and neutrophil products in bronchoalveolar lavage fluid of a patient

H. Mukae, N. Matsumoto, J. Ashitani, H. Mashimoto, J. Kadota, M. Nakazato, S. Kohno, S. Matsukura
1996 European Respiratory Journal  
N Ne eu ut tr ro op ph hi il l--r re el la at te ed d c cy yt to ok ki in ne es s a an nd d n ne eu ut tr ro op ph hi il l p pr ro od du uc ct ts s i in n b br ro on nc ch ho oa al lv ve eo ol la ar r l la av va ag ge e f fl lu ui id d o of f a a p pa at ti ie en nt t ABSTRACT: We report a case of Wegener's granulomatosis (WG), with neutrophil accumulation in bronchoalveolar lavage fluid (BALF). Peripheral blood neutrophilia was present but the anti-neutrophil cytoplasmic antibody (ANCA) was
more » ... ative. The serum and BALF levels of neutrophil-related cytokines, including interleukin (IL)-8, granulocyte colony-stimulating factor (G-CSF) and IL-1β, were increased, particularly in BALF. Plasma and BALF levels of neutrophil elastase and defensins, which are released by neutrophils and are potentially toxic to cells, were also elevated. Our findings suggest that neutrophils and neutrophil-related cytokines may play an important role in the pathogenesis of anti-neutrophil cytoplasmic antibody negative as well as anti-neutrophil cytoplasmic antibody positive Wegener's granulomatosis.
doi:10.1183/09031936.96.09091950 pmid:8880117 fatcat:ui7aeexhpnckvp2dsgrhowq4ni