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High density oligonucleotide microarrays present a big challenge for statistical data processing methods which aim to separate changes induced by experimental factors from those caused by artifacts and measurement inaccuracies. Despite huge advances in the field of microarray probe design methods, the signal variation between probes that target a single transcript is substantially larger than their between-replicate array variability, suggesting a large influence of various probe-specificdoi:10.3390/s140100532 pmid:24385030 pmcid:PMC3926573 fatcat:iqbulq524rg7blrxz5uxyjsfqa