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Age-related cognitive decline is rooted in alterations in brain integrity as well as in sleep-wake regulation. Here, we investigated whether preserved sleep-wake regulation of cortical function during wakefulness could represent a positive factor for cognitive fitness in aging, independently of early age-related alterations in brain structure associated with Alzheimer's disease neuropathology. We quantified slow waves generation during sleep and cortical excitability dynamics during prolongeddoi:10.1101/644096 fatcat:heveynlchvhv5n3kubysapcvaq