Pharmacoeconomics of three therapeutic schemes for anti-tuberculosis therapy induced liver injury in China

Yu Chen, Peng Ye, Chongwu Ren, Pengfei Ren, Zheng Ma, Lin Zhang, Wenliang Zhou, Changjie Jiang
<span title="2018-03-21">2018</span> <i title="Walter de Gruyter GmbH"> <a target="_blank" rel="noopener" href="" style="color: black;">Open Medicine</a> </i> &nbsp;
To evaluate the pharmacoeconomics of three therapeutic schemes in treating anti-tuberluosis therapy -induced liver injury (anti-TB DILI). Methods In the construction of a decision tree model, the efficacy and safety parameters came from the results of the randomized, controlled trial conducted here, the effect parameters were derived from expert advice, and the cost parameters, such as usage specification, number, and unit price, came from literature, expert advice, and so on. Results The
more &raquo; ... ffectiveness analysis (CEA) based on the effect degrees showed that bicyclol had the best effect (4.63562). The incremental cost-effectiveness ratio (ICER) (206.03270) of bicyclol was the lowest. The cost-effectiveness ratio of silibinin was the lowest (68.59987). The CEA based on the complete normalization rate showed that bicyclol had the highest complete normalization rate (83.562%), the lowest cost-effectiveness ratio (4.63627), and the smallest ICER (4.63504). Sensitivity analyses proved the robustness of the results. Conclusions Bicyclol is the most cost-effective therapy and the preferred choice for treating anti-TB DILI.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="">doi:10.1515/med-2018-0010</a> <a target="_blank" rel="external noopener" href="">pmid:29607414</a> <a target="_blank" rel="external noopener" href="">pmcid:PMC5874510</a> <a target="_blank" rel="external noopener" href="">fatcat:h5dkz5zpvnebrg3http3bp4agi</a> </span>
<a target="_blank" rel="noopener" href="" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href=""> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> </button> </a> <a target="_blank" rel="external noopener" href="" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> </button> </a>