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The neurotransmitter acetylcholine (ACh) plays a critical role in brain circuits mediating motor control, attention, learning and memory. Cholinergic dysfunction is associated with multiple brain disorders including Alzheimer's Disease, addiction, schizophrenia and Attention-Deficit Hyperactivity Disorder (ADHD). The presynaptic choline transporter (CHT, SLC5A7) is the major, ratelimiting determinant of ACh production in the brain and periphery and is consequently upregulated during tasks thatdoi:10.1007/s11689-009-9033-8 pmid:21547719 pmcid:PMC3164006 fatcat:7bpjq7ryd5aeznpv563dzc55me