Synthesis, Crystal Structure and anticancer activities of an unusual inorganic–organic hybrid complex with a sandwiched ribbon structure

Jing Hu, Jiajia Qi, Yun Luo, Tianyue Yin, Jie Wang, Chunjing Wang, Wenge Li, Lili Liang
2021 Arabian Journal of Chemistry  
An inorganic-organic hybrid complex [Cd 7 Cl 14 L 2 (EtOH) 2 ]n (L = 4-Aminoantipyrine) was synthesised by solvothermal reaction and characterised by X-ray single-crystal diffraction analyses. It has unusual seven-nuclear cadmium chloride structure, which extends along the a-axis to form an infinite flat ribbon structure with the thickness of 3 Å and the width of 18 Å . The flat inorganic ribbon is wrapped in the two edge sides by organic molecules to form a sandwich structure. The MTT assay
more » ... ult displayed that the synthesised complex possessed antiproliferative activity potentials against the HCT-116, HepG2 and MCF-7 cancer cell lines. After 72 h treatment, the complex had a potent inhibitory effect on HCT-116 cells, and the IC 50 value was 1.05 ± 0.06 (lg/mL). The cell cycle and apoptosis experiments showed that the complex remarkably induced apoptosis and arrested the HCT-116 cancer cell lines in the G1/G0 phase related to the concentration.
doi:10.1016/j.arabjc.2021.103117 fatcat:qn5eynnxyzh4pcanbavvcng5ci