Microencapsulation of Ascorbic Acid for Cosmetic by Utilizing Self-assembly of Phase Separated Polymer

Shiro Nakai, Akito Nakai, Takashi Michida
2016 Chemical and pharmaceutical bulletin  
Micrometer-sized polymer particles encapsulated ascorbic acid (vitamin C; VC) were successfully prepared by the three types of the self-assembling method, those are, phase separation and self-assembly of added polymer at the oil-water interface in emulsion, microsuspension polymerization utilizing the selfassembling of phase separated polymer (SaPSeP) method, and their hybrid method. In the stability study at 50°C for 2 months, the three kinds of capsule particles exhibited effective protection
more » ... ffective protection of VC from the interaction with other components in cosmetic consisting of water-in-oil (W/O) emulsion. The encapsulated VC was easily released from the capsule particles by an excess of water. These encapsulation methods will be useful for the stabilization of water-soluble substances in cosmetic consisting of W/O emulsion.
doi:10.1248/cpb.c16-00384 pmid:27725506 fatcat:tp5mbis7srdbjobzee2z34gv44