Reirradiation of paraaortic lymph node metastasis by brachytherapy with hyaluronate injection via paravertebral approach: With DVH comparison to IMRT

Kazushi Kishi, Tetsuo Sonomura, Shintaro Shirai, Yasutaka Noda, Morio Sato, Hitoshi Ikushima, Ryoong-Jin Oh
2013 Brachytherapy  
PURPOSE/INTRODUCTION: To safely irradiate retroperitoneal targets as paraaortic lymph node by separating abdominal at-risk organs from the target during irradiation, we created a percutaneous paravertebral approach of high-dose-rate brachytherapy with hyaluronate gel injection (HGI). We report a case treated with this technique. METHODS AND MATERIALS: We encountered a patient with symptomatic regrowth of paraaortic lymph node metastasis from prostatic cancer. He had previously received 58.4 Gy
more » ... y received 58.4 Gy of radiotherapy to the same region 12 months prior. Brachytherapy needles and a HGI needle were deployed via the paravertebral approach under local anesthesia at our outpatient clinic. RESULTS: A single dose of 22.5 Gy (equivalent to 60.94 Gy in 2 Gy per fraction schedule calculated at a/b 5 10) was delivered to the target, with preservation of the surrounding small intestine by HGI with D 2cc (minimum dose to the most irradiated volume of 2 mL) of 5.05 Gy. Therapeutic ratio was 3.64 times higher for this brachytherapy plan compared with an intensity-modulated radiation therapy plan. At followup at 1 year after brachytherapy, the symptoms had disappeared, tumor size had reduced with no fluorodeoxyglucose accumulation, and prostate-specific antigen level had decreased. CONCLUSION: We consider that high-dose-rate brachytherapy with the HGI procedure offers effective treatment even in this type of reirradiation situation. Ó
doi:10.1016/j.brachy.2011.12.004 pmid:22209390 fatcat:jsgynbesp5hj5mudi25fbk4nka